The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

DE ANDRADE, J. P.; GIORDANI, R. B.; TORRAS-CLAVERIA, L.; PIGNI, N. B.; BERKOV, S.; FONT-BARDIA, M.; CALVET, T.; KONRATH, E.; BUENO, K.; SACHETT, L. G.; DUTILH, J. H.; DE SOUZA BORGES, W.; VILADOMAT, F.; HENRIQUES, A. T.; NAIR, J. J.; ZUANAZZI, J. A. S.; BASTIDA, J.

PHYTOCHEMISTRY REVIEWS

SPRINGER

Lugar: Berlin; Año: 2015 vol. 15 p. 147 - 147

1568-7767

ine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC?MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.